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MSH6 PROTEIN



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Msh6 protein

Recombinant Human MSH6 protein is a Wheat germ Protein fragment to aa range and validated in WB, ELISA, SDS-PAGE. The human MSH6 protein was first reported in as G/T mismatch Binding Protein (GTBP), binding partner of hMSH2 to form the MutSα complex [7, 11,19]. The human MSH6 gene includes 10 exons that encompass a total genomic sequence of 24 kilobases, and is located on the petite arm of chromosome 2 (2p), within one megabase of hMSH2. Protein MSH6. Thus, MSH6 protein may play a subtly different biochemical role in mismatch repair than MLH1 or MSH2 proteins, as evidenced by the difference in cancer risk and the more frequent instability of mononucleotide repeats compared with dinucleotide repeats in tumors from MSH6 mutation carriers (18).

Six Microseconds of Protein Folding

A DNA sequence encoding the Homo sapiens (Human) DNA mismatch repair protein Msh6, was expressed in the hosts and tags indicated. MSH6 functions by repairing mutations occurring during DNA replication, in normal proliferating cells. Disclaimer. Mismatch Repair Protein (MSH6) is recommended. Mismatch Repair (MMR) Protein Immunohistochemistry Only, Tumor When this test is ordered, MLH1, MSH2, MSH6, and PMS2 stains will always be performed at. The mutation pathway is initiated by the activation-induced cytidine deaminase (AID) protein, which is only expressed in B cells (1, 2). AID deaminates cytosine. MSH6 Antibody is a Rabbit Polyclonal antibody against MSH6. This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein. MSH6 (DNA Mismatch Repair Protein) MonoSpecific Antibody. Reactivity Human. Tested In ELISA, WB. Formats Unconjugated. Isotype IgG2b, kappa. From: $

GEOMI - DNA mismatch repair proteins

Elabscience is a famous biology science research reagents manufacturer. Our MutS Protein Homolog 6(MSH6) Monoclonal Antibody price is reasonable. Recombinant MutS Homolog 6 (E. Coli) (MSH6) Protein (His tag). Species: Human. Source: Insect Cells. Order product ABIN Anti-MSH6 (DNA Mismatch Repair Protein) Monoclonal Antibody(Clone: MSH6/). Share.

Msh6p is one of 6 E. coli MutS homologs in S. cerevisiae (6). Mutations in the human MSH6 protein have been identified in an endometrial carcinoma cell line . Recombinant Human MSH6 protein is a Wheat germ Protein fragment to aa range and validated in WB, ELISA, SDS-PAGE. MSH6 Component of the post-replicative DNA mismatch repair system (MMR). · Protein type: DNA-binding · Chromosomal Location of human Ortholog: 2p · Cellular.

MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the. DNA mismatch repair protein Msh6. Show all. Predicted intracellular proteins. Intracellular proteins predicted by MDM and MDSEC Cancer-related genes. DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha kDa subunit) (p) Homo.

Protein MSH6. Thus, MSH6 protein may play a subtly different biochemical role in mismatch repair than MLH1 or MSH2 proteins, as evidenced by the difference in cancer risk and the more frequent instability of mononucleotide repeats compared with dinucleotide repeats in tumors from MSH6 mutation carriers (18). The Human mutS MSH2 and MSH6 protein sequences were retrieved from the UniProt database with the respective IDs P and P The amino acid positions in the protein-protein interacting region of MSH6-MSH6 were extracted from the PDBsum server. The missense mutations positioned in the PPI region of MSH6-MSH6 were collected from the public. MSH6 (GTBP) protein expression summary. This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately aa, called the Walker-A adenine nucleotide binding motif, exists in MutS www.4-artists.rund: p PomBase - protein coding gene - msh6 (SPCCc) - MutS protein homolog. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome). MSH6, DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha. MSH6 (DNA Mismatch Repair Protein). Calibre Catalog Number: NEOMSM3-P1ABX. Category: Antibodies. Market: Life Sciences. Brand: NeoBiotechnologies.

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Recombinant Human MSH6 protein is a Wheat germ Protein fragment to aa range and validated in WB, ELISA, SDS-PAGE. MSH6 protein expression was detected in all pretreatment (17 of 17) cases examined but, notably, expression was lost in 7 of 17 (41%) recurrences from matched post-XRT + temozolomide cases (P = ). Loss of MSH6 was not associated with O (6)-methylguanine methyltransferase status. Measurements of in vivo tumor growth using three-dimensional reconstructed magnetic resonance . The human MSH6 protein was first reported in as G/T mismatch Binding Protein (GTBP), binding partner of hMSH2 to form the MutSα complex [7, 11,19]. The human MSH6 gene includes 10 exons that encompass a total genomic sequence of 24 kilobases, and is located on the petite arm of chromosome 2 (2p), within one megabase of hMSH2. Apr 28,  · We, therefore, optimized MAPP for MSH6 and then integrated SIFT, PolyPhen-2 and two properties from protein structure, namely solvent accessibility and the volume change in amino acid residues. We joined these properties on the logistic regression model and compared the prediction performance with MAPP, SIFT, PolyPhen-2 and PON-MMR [ 22 ]. NeoBiotechnologies Anti-MSH6 (DNA Mismatch Repair Protein) Monoclonal (MSH6, ), Catalog # MSM5-P1ABX. Tested in Western Blot (WB). View mouse Msh6 Chr with: phenotypes, sequences, polymorphisms, proteins, references, function, expression. MSH6 K13T does not lie within any known functional domains of the Msh6 protein (www.4-artists.ru). K13T demonstrates intermediate mismatch repair activity compared. MutS, E. COLI, HOMOLOG OF, 6. G/T MISMATCH-BINDING PROTEIN; GTBP. HGNC Approved Gene Symbol: MSH6. Cytogenetic location: 2p Genomic coordinates. The name MSH6 stands for "MutS homolog 6." The gene is located on chromosome 2. The MSH6 gene protein plays an important role in repairing. Description, This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched. Anti-DNA mismatch repair protein Msh6 (MSH6) from Rabbit - unconj. - Dianova Int. To date, five mismatch-repair (MMR) genes, MLH1, MSH2, MSH6, MSH3 and PMS2, are known to be involved in human MMR function. Two of those, MLH1 and MSH2. MLH1 forms heterodimers with other mismatch repair proteins as well, Loss of MSH2 and MSH6 protein staining usually indicates a germline MSH2 mutation. Gene Summary ; Location: 2p ; Summary: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the.
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